A comparison of changes in the nucleus basalis and locus caeruleus in Alzheimer's disease. | Zendy

David Mann | Zendy; P. O. Yates | Zendy; B. Marcyniuk | Zendy

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A comparison of changes in the nucleus basalis and locus caeruleus in Alzheimer's disease.

Author(s) -

David Mann,

P. O. Yates,

B. Marcyniuk

Publication year - 1984

Publication title -

journal of neurology neurosurgery and psychiatry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.391

H-Index - 206

eISSN - 1468-330X

pISSN - 0022-3050

DOI - 10.1136/jnnp.47.2.201

Subject(s) - nucleus basalis , locus (genetics) , locus coeruleus , nucleus , disease , neuroscience , biology , medicine , genetics , pathology , gene , central nervous system , cholinergic neuron

In 22 patients with Alzheimer's disease loss of neurons from the nucleus basalis of Meynert and locus caeruleus averaged 58% and 71% respectively with nucleolar volume being reduced by 30% in both. These changes were greater in those patients under 80 years of age and in such patients damage to the locus was more severe than that to the nucleus basalis. In older patients (over 80 years) changes were similar in extent in both regions.

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