The role of cerebrospinal fluid 14-3-3 and other proteins in the diagnosis of sporadic Creutzfeldt-Jakob disease in the UK: a 10-year review | Zendy

Gurjit Chohan | Zendy; Catherine Pennington | Zendy; J. Mackenzie | Zendy; Mary Andrews | Zendy; Dawn Everington | Zendy; R. G. Will | Zendy; Richard Knight | Zendy; A. J. E. Green | Zendy

Open Access

The role of cerebrospinal fluid 14-3-3 and other proteins in the diagnosis of sporadic Creutzfeldt-Jakob disease in the UK: a 10-year review

Author(s) -

Gurjit Chohan,

Catherine Pennington,

J. Mackenzie,

Mary Andrews,

Dawn Everington,

R. G. Will,

Richard Knight,

A. J. E. Green

Publication year - 2010

Publication title -

journal of neurology neurosurgery and psychiatry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.391

H-Index - 206

eISSN - 1468-330X

pISSN - 0022-3050

DOI - 10.1136/jnnp.2009.197962

Subject(s) - cerebrospinal fluid , predictive value , medicine , pathology , tau protein , positive predicative value , gastroenterology , disease , alzheimer's disease

It is 10 years since the detection of cerebrospinal fluid (CSF) 14-3-3 was included in the diagnostic criteria for sporadic Creutzfeldt-Jakob disease (sCJD) by the WHO. Since that time, other CSF proteins, such as S100b and tau protein, have been proposed as surrogate markers for sCJD. The authors aimed to investigate the diagnostic value of each of these three proteins.

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