Open AccessDeep brain stimulation activation volumes and their association with neurophysiological mapping and therapeutic outcomes
Author(s) -
Christopher B. Maks,
Christopher R. Butson,
Benjamin L. Walter,
Jerrold L. Vitek,
Cameron C. McIntyre
Publication year - 2008
Publication title -
journal of neurology, neurosurgery and psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.391
H-Index - 206
eISSN - 1468-330X
pISSN - 0022-3050
DOI - 10.1136/jnnp.2007.126219
Subject(s) - subthalamic nucleus , deep brain stimulation , neurostimulation , neuroscience , context (archaeology) , neuroimaging , neuroanatomy , neurophysiology , diffusion mri , brain stimulation , functional neuroimaging , medicine , psychology , stimulation , parkinson's disease , magnetic resonance imaging , radiology , disease , paleontology , biology
Despite the clinical success of deep brain stimulation (DBS) for the treatment of Parkinson's disease (PD), little is known about the electrical spread of the stimulation. The primary goal of this study was to integrate neuroimaging, neurophysiology and neurostimulation data sets from 10 patients with PD, unilaterally implanted with subthalamic nucleus (STN) DBS electrodes, to identify the theoretical volume of tissue activated (VTA) by clinically defined therapeutic stimulation parameters.