Open AccessSafety and tolerability of adjunctive tolcapone treatment in patients with early Parkinson's disease
Author(s) -
Andrew J. Lees,
Vlad Ratziu,
Eduardo Tolosa,
Wolfgang H. Oertel
Publication year - 2007
Publication title -
journal of neurology, neurosurgery and psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.391
H-Index - 206
eISSN - 1468-330X
pISSN - 0022-3050
DOI - 10.1136/jnnp.2006.097154
Subject(s) - tolerability , placebo , discontinuation , medicine , elevated transaminases , adverse effect , gastroenterology , anesthesia , alternative medicine , pathology
The safety and tolerability of adjunctive tolcapone initiated simultaneously with levodopa was evaluated with a focus on increases in liver transaminase and hepatotoxicity.