DISSEMINATED SCLEROSIS TREATED WITH ISONIAZID WITH A METHOD OF EVALUATING CHRONIC NEUROLOGICAL DISORDERS

Material Eleven patients suffering from undoubted disseminated sclerosis were studied. They had all been seen on account of a recent relapse, or, in one case, because of steady deterioration; patients manifesting the initial features of the disease were not included. Five were men and six were women with ages ranging from 27 to 48 years (mean 38 years). The disease had been present for periods of two to 21 years with a mean duration of 10. However, in only one case had it been progressive from the onset, the remainder having experienced several relapses before permanent disability appeared; the mean duration of the latter was five years. In all but one an aggravation of the existing deficits or the appearance of new features had occurred within the last two years-the average for this being nine and a third months.