Critical evaluation of monoclonal antibody staining in breast carcinoma. | Zendy

David M. Parham | Zendy; G Coghill | Zendy; A J Robertson | Zendy

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Critical evaluation of monoclonal antibody staining in breast carcinoma.

Author(s) -

David M. Parham,

G Coghill,

A J Robertson

Publication year - 1989

Publication title -

journal of clinical pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.1

H-Index - 127

eISSN - 1472-4146

pISSN - 0021-9746

DOI - 10.1136/jcp.42.8.810

Subject(s) - staining , monoclonal antibody , pathology , immunoperoxidase , breast carcinoma , monoclonal , carcinoma , immunohistochemistry , antibody , medicine , biology , breast cancer , immunology , cancer

The immunoperoxidase staining of 84 primary invasive breast carcinomas with four monoclonal antibodies (BRST-1, HMFG1, EMA, B72.3) was evaluated by semiquantitative light microscopical examination and quantitative image analysis. Major differences in the staining of the tumours for each of the monoclonal antibodies was observed. Correlation between monoclonal antibody staining and patient age, survival, histological grade, tumour diameter and cellularity was also carried out. This showed a significant association between histological grade and staining with BRST-1 and EMA.

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