Recruitment and plasmapheresis of donors to provide human antitetanus immunoglobulin. | Zendy

Ian A. Cook | Zendy; David Ross | Zendy; Ingelise J. Gordon | Zendy

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Recruitment and plasmapheresis of donors to provide human antitetanus immunoglobulin.

Author(s) -

Ian A. Cook,

David Ross,

Ingelise J. Gordon

Publication year - 1976

Publication title -

journal of clinical pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.1

H-Index - 127

eISSN - 1472-4146

pISSN - 0021-9746

DOI - 10.1136/jcp.29.3.211

Subject(s) - plasmapheresis , tetanus , tetanus antitoxin , booster dose , medicine , antibody , antitoxin , immunology , vaccination , biology , immunization , microbiology and biotechnology , toxin

A method is described whereby about 100 litres of plasma containing 10-50 IU/ml tetanus antitixin was obtained, from which were prepared 5000 X 250 IU doses of human antitetanus immunoglobulin. Of 40 blood donors who received a booster injection of tetanus vaccine BP, 33 were plasmapheresed each week over a 10-12 week period starting three weeks after the injection. Twenty-two of these donors provided 90% of the total plasma, the antitoxin content of which averaged 23.6 IU/ml over the 10-12 week period.

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