Two cases of opportunistic parasite infections in patients receiving alemtuzumab | Zendy

Guillaume Désoubeaux | Zendy; Charline Caumont | Zendy; Christophe Passot | Zendy; Caroline Dartigeas | Zendy; Éric Bailly | Zendy; J. Chandenier | Zendy; Thanh Haï Duong | Zendy

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Two cases of opportunistic parasite infections in patients receiving alemtuzumab

Author(s) -

Guillaume Désoubeaux,

Charline Caumont,

Christophe Passot,

Caroline Dartigeas,

Éric Bailly,

J. Chandenier,

Thanh Haï Duong

Publication year - 2011

Publication title -

journal of clinical pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.1

H-Index - 127

eISSN - 1472-4146

pISSN - 0021-9746

DOI - 10.1136/jclinpath-2011-200403

Subject(s) - alemtuzumab , microsporidiosis , context (archaeology) , opportunistic infection , medicine , aids related opportunistic infections , immunology , medical diagnosis , intensive care medicine , biology , human immunodeficiency virus (hiv) , pathology , sida , viral disease , malaria , protozoal disease , antibody , paleontology

Two cases are reported of rare digestive opportunistic parasites in patients being treated with alemtuzumab for lymphoid haematological malignancies. In both patients, classical biological examinations were insufficient to reach the diagnosis. Only specific parasitological techniques enabled diagnoses of cryptosporidiosis and microsporidiosis, respectively. In both cases, cellular immune reconstitution was sufficient to eradicate these opportunistic infections. In this context, parasitological diagnosis is often underestimated by medical practitioners, so immunologists and oncohaematologists need to be aware of this kind of opportunistic pathogen.

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