Open AccessRNA helicase DDX5 enables STAT1 mRNA translation and interferon signalling in hepatitis B virus replicating hepatocytes
Author(s) -
Jiaren Sun,
Guanhui Wu,
Florentin Pastor,
Naimur Rahman,
WenHung Wang,
Zhengtao Zhang,
Philippe Merle,
Lijian Hui,
Anna Salvetti,
David Durantel,
Danzhou Yang,
Ourania Andrisani
Publication year - 2021
Publication title -
gut
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.413
H-Index - 293
eISSN - 1468-3288
pISSN - 0017-5749
DOI - 10.1136/gutjnl-2020-323126
Subject(s) - rna helicase a , biology , gene knockdown , untranslated region , virology , rna , microbiology and biotechnology , interferon , messenger rna , helicase , cell culture , genetics , gene
RNA helicase DDX5 is downregulated during HBV replication and poor prognosis HBV-related hepatocellular carcinoma (HCC). The objective of this study is to investigate the role of DDX5 in interferon (IFN) signalling. We provide evidence of a novel mechanism involving DDX5 that enables translation of transcription factor STAT1 mediating the IFN response.