Open AccessDexamethasone prevents visceral hyperalgesia but not colonic permeability increase induced by luminal protease-activated receptor-2 agonist in rats
Author(s) -
R Róka,
Afifa Ait-Belgnaoui,
Christel Salvador–Cartier,
R. GarciaVillar,
Jean Fioramonti,
Hélène Eutamene,
Lionel Buéno
Publication year - 2007
Publication title -
gut
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.413
H-Index - 293
eISSN - 1468-3288
pISSN - 0017-5749
DOI - 10.1136/gut.2006.115352
Subject(s) - dexamethasone , medicine , endocrinology , hyperalgesia , irritable bowel syndrome , mast cell , pharmacology , agonist , receptor , immunology , nociception
Low-grade inflammation may play a role in the pathogenesis of irritable bowel syndrome (IBS). Although corticosteroids are potent inhibitors of inflammatory processes, only one study with corticosteroids in patients with postinfectious IBS exists, which suggests that prednisolone is not an effective treatment for IBS symptoms.