Open AccessActive cytomegalovirus retinitis after the start of antiretroviral therapy
Author(s) -
David Heiden,
NiNi Tun,
Frank Smithuis,
Jeremy D. Keenan,
Catherine E. Oldenburg,
Gary N. Holland,
W. Lawrence Drew
Publication year - 2018
Publication title -
british journal of ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.016
H-Index - 153
eISSN - 1468-2079
pISSN - 0007-1161
DOI - 10.1136/bjophthalmol-2018-312406
Subject(s) - retinitis , medicine , cytomegalovirus retinitis , cytomegalovirus , cart , antiretroviral therapy , aids related opportunistic infections , ophthalmoscopy , human cytomegalovirus , immunology , pediatrics , herpesviridae , human immunodeficiency virus (hiv) , viral disease , sida , viral load , ophthalmology , virus , retinal , mechanical engineering , engineering
Patients with AIDS-related cytomegalovirus (CMV) retinitis receiving combined antiretroviral therapy (cART), but not specific anti-CMV therapy, consistently showed active retinitis for several months. Delayed diagnosis and treatment of CMV retinitis may have severe consequences. Patients first entering care with advanced HIV infection and vulnerability to reactivation of latent CMV infection should be screened immediately for CMV retinitis by dilated indirect ophthalmoscopy and treated with specific anti-CMV therapy without delay, in addition to cART.