Determination of a gene and environment risk model for age-related macular degeneration | Zendy

Jane Whitney Gibson | Zendy; Angela J. Cree | Zendy; Andrew Collins | Zendy; Andrew Lotery | Zendy; Sarah Ennis | Zendy

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Determination of a gene and environment risk model for age-related macular degeneration

Author(s) -

Jane Whitney Gibson,

Angela J. Cree,

Andrew Collins,

Andrew Lotery,

Sarah Ennis

Publication year - 2010

Publication title -

british journal of ophthalmology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.016

H-Index - 153

eISSN - 1468-2079

pISSN - 0007-1161

DOI - 10.1136/bjo.2010.182568

Subject(s) - linkage disequilibrium , haplotype , medicine , macular degeneration , single nucleotide polymorphism , genetics , genetic association , population , logistic regression , genetic model , gene , genotype , biology , ophthalmology , environmental health

We have recently identified an association between age-related macular degeneration (AMD) and genetic variants in the serpin peptidase inhibitor, clade G, member 1 (SERPING1) gene. In the current study we interrogated the genomic region in linkage disequilibrium (LD) with the SERPING1 gene, and modelled the contribution to disease of known genetic and environmental AMD risk factors.

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