Open AccessLongitudinal analysis of ANA in the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort
Author(s) -
May Y. Choi,
Ann E. Clarke,
Murray B. Urowitz,
John G. Hanly,
Yvan St-Pierre,
Caroline Gordon,
Sang Cheol Bae,
Juanita Romero-Díaz,
Jorge SánchezGuerrero,
Sasha Bernatsky,
Daniel J. Wallace,
David Isenberg,
Anisur Rahman,
Joan T. Merrill,
Paul R. Fortin,
Dafna Gladman,
Ian N Bruce,
Michelle Petri,
Ellen M. Ginzler,
Mary Anne Dooley,
Rosalind RamseyGoldman,
Susan Manzi,
Andreas Jönsen,
Graciela S. Alarcón,
Ronald van Vollenhoven,
Cynthia Aranow,
Meggan Mackay,
Guillermo RuizIrastorza,
S. Sam Lim,
Murat İnanç,
Ken Kalunian,
Søren Jacobsen,
Christine A. Peschken,
Diane L. Kamen,
Anca Askanase,
Jill P. Buyon,
Karen H. Costenbader,
Marvin J. Fritzler
Publication year - 2022
Publication title -
annals of the rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.333
H-Index - 240
eISSN - 1468-2060
pISSN - 0003-4967
DOI - 10.1136/annrheumdis-2022-222168
Subject(s) - medicine , anti nuclear antibody , serology , cohort , systemic lupus erythematosus , mcnemar's test , autoantibody , kappa , gastroenterology , immunology , antibody , disease , statistics , mathematics , linguistics , philosophy
A perception derived from cross-sectional studies of small systemic lupus erythematosus (SLE) cohorts is that there is a marked discrepancy between antinuclear antibody (ANA) assays, which impacts on clinicians' approach to diagnosis and follow-up. We compared three ANA assays in a longitudinal analysis of a large international incident SLE cohort retested regularly and followed for 5 years.