Open AccessElevated Cerebrospinal Fluid Anti-CD4 Autoantibody Levels in HIV Associate with Neuroinflammation
Author(s) -
Da Cheng,
Zhenwu Luo,
Xiaoyu Fu,
Sophie Stephenson,
Clara Di Germanio,
Philip J. Norris,
Dietmar Fuchs,
Lishomwa C. Ndhlovu,
Quan-Zhen Li,
Henrik Zetterberg,
Magnus Gisslén,
Richard W. Price,
Shifang Peng,
Wei Jiang
Publication year - 2022
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.502
H-Index - 51
ISSN - 2165-0497
DOI - 10.1128/spectrum.01975-21
Subject(s) - neuroinflammation , immunology , antibody dependent cell mediated cytotoxicity , cerebrospinal fluid , cd8 , medicine , immunoglobulin g , cd14 , immune system , antibody , inflammation , monoclonal antibody
This study reports that an autoantibody presents in the CNS of HIV patients and that its levels in the CSF correlate with some markers of neuroinflammation.