Open AccessInactivation of the Response Regulator AgrA Has a Pleiotropic Effect on Biofilm Formation, Pathogenesis and Stress Response in Staphylococcus lugdunensis
Author(s) -
Marion Aubourg,
Marine Pottier,
Albertine Léon,
Benoı̂t Bernay,
Anne Dhalluin,
Margherita Cacaci,
Riccardo Torelli,
Pierre Ledormand,
Cécilia Martini,
Maurizio Sanguinetti,
Michel Auzou,
François Gravey,
JeanChristophe Giard
Publication year - 2022
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.502
H-Index - 51
ISSN - 2165-0497
DOI - 10.1128/spectrum.01598-21
Subject(s) - agra , virulence , staphylococcus lugdunensis , quorum sensing , biology , response regulator , biofilm , mutant , microbiology and biotechnology , autoinducer , regulator , genetics , staphylococcus aureus , staphylococcus , gene , bacteria , ecology
Although belonging to the natural human skin flora,Staphylococcus lugdunensis is recognized as a particularly aggressive and destructive pathogen. This study aimed to characterize the role of the response regulator AgrA, which is a component of the quorum-sensingagr system and known to be a major element in the regulation of pathogenicity and biofilm formation inStaphylococcus aureus .