Open AccessSARS-CoV-2 Point Mutation and Deletion Spectra and Their Association with Different Disease Outcomes
Author(s) -
Brenda MartínezGonzález,
María Eugenia Soria,
Lucía Vázquez-Sirvent,
Cristina FerrerOrta,
Rebeca Lobo-Vega,
Pablo Mínguez,
Lorena de la Fuente,
Carlos Lloréns,
Beatriz Soriano,
Ricardo Ramos-Ruíz,
Marta Cortón,
Rosario LópezRodríguez,
Carlos GarcíaCrespo,
Isabel Gallego,
Ana Isabel de Ávila,
Jordi Gómez,
Luis Enjuanes,
Llanos SalarVidal,
Jaime Esteban,
R. Fernández-Roblas,
Ignacio Gadea,
Carmen Ayuso,
Javier Ruíz-Hornillos,
N. Verdaguer,
Esteban Domingo,
Celia Perales
Publication year - 2022
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.502
H-Index - 51
ISSN - 2165-0497
DOI - 10.1128/spectrum.00221-22
Subject(s) - biology , point mutation , genetics , mutant , mutation , virology , amplicon , mutation frequency , coding region , polymerase chain reaction , gene
The study shows that mutant spectra of SARS-CoV-2 from diagnostic samples differ in point mutation abundance and complexity and that significantly larger values were observed in virus from patients who developed mild COVID-19 symptoms. Mutant spectrum complexity is not a uniform trait among isolates. The nature and location of low-frequency amino acid substitutions present in mutant spectra anticipate great potential for phenotypic diversification of SARS-CoV-2.