Role of VapBC12 Toxin-Antitoxin Locus in Cholesterol-Induced Mycobacterial Persistence | Zendy

Sakshi Talwar | Zendy; Manitosh Pandey | Zendy; Chandresh Sharma | Zendy; Rintu Kutum | Zendy; Josephine Lum | Zendy; Daniel Carbajo | Zendy; Renu Goel | Zendy; Michael Poidinger | Zendy; Debasis Dash | Zendy; Amit Singhal | Zendy; Amit Kumar Pandey | Zendy

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Role of VapBC12 Toxin-Antitoxin Locus in Cholesterol-Induced Mycobacterial Persistence

Author(s) -

Sakshi Talwar,

Manitosh Pandey,

Chandresh Sharma,

Rintu Kutum,

Josephine Lum,

Daniel Carbajo,

Renu Goel,

Michael Poidinger,

Debasis Dash,

Amit Singhal,

Amit Kumar Pandey

Publication year - 2020

Publication title -

msystems

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.931

H-Index - 39

ISSN - 2379-5077

DOI - 10.1128/msystems.00855-20

Subject(s) - antitoxin , persistence (discontinuity) , drug resistance , toxin , regimen , medicine , locus (genetics) , biology , microbiology and biotechnology , genetics , gene , geotechnical engineering , engineering

The current TB treatment regimen involves a combination of drugs administered for an extended duration that could last for 6 months to 2 years. This could lead to noncompliance and the emergence of newer drug resistance strains.

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