Molecular Mechanisms of the Toll-Like Receptor, STING, MAVS, Inflammasome, and Interferon Pathways | Zendy

Nathan P. Manes | Zendy; Aleksandra NitaLazar | Zendy

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Molecular Mechanisms of the Toll-Like Receptor, STING, MAVS, Inflammasome, and Interferon Pathways

Author(s) -

Nathan P. Manes,

Aleksandra NitaLazar

Publication year - 2021

Publication title -

msystems

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.931

H-Index - 39

ISSN - 2379-5077

DOI - 10.1128/msystems.00336-21

Subject(s) - inflammasome , sting , pattern recognition receptor , signal transduction , innate immune system , computational biology , biology , mechanism (biology) , receptor , toll like receptor , interferon , microbiology and biotechnology , immunology , genetics , engineering , physics , quantum mechanics , aerospace engineering

Pattern recognition receptors (PRRs) form the front line of defense against pathogens. Many of the molecular mechanisms that facilitate PRR signaling have been characterized in detail, which is critical for the development of accurate PRR pathway models at the molecular interaction level. These models could support the development of therapeutics for numerous diseases, including sepsis and COVID-19. This review describes the molecular mechanisms of the principal signaling interactions of the Toll-like receptor, STING, MAVS, and inflammasome pathways. A detailed molecular mechanism network is included as Data Set S1 in the supplemental material.

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