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The IS 26  family includes the ISs that are commonly found associated with antibiotic resistance genes in multiply resistant Gram-negative and Gram-positive bacteria. IS 26  is most prevalent in Gram-negative species and can generate the clusters of antibiotic resistance genes interspersed with directly oriented IS 26  seen in multiply resistant pathogens.

Targeted Conservative Cointegrate Formation Mediated by IS 26 Family Members Requires Sequence Identity at the Reacting End