Toxoplasma Uses GRA16 To Upregulate Host c-Myc | Zendy

Michael W. Panas | Zendy; John C. Boothroyd | Zendy

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Toxoplasma Uses GRA16 To Upregulate Host c-Myc

Author(s) -

Michael W. Panas,

John C. Boothroyd

Publication year - 2020

Publication title -

msphere

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.749

H-Index - 39

ISSN - 2379-5042

DOI - 10.1128/msphere.00402-20

Subject(s) - intracellular , host (biology) , intracellular parasite , pathogen , downregulation and upregulation , biology , microbiology and biotechnology , virology , genetics , gene

The proto-oncogene c- Myc plays a crucial role in the growth and division of many animal cells. Previous studies have identified an active upregulation of c-Myc by Toxoplasma tachyzoites, suggesting the existence of one or more exported “effector” proteins. The identity of such an effector, however, has not previously been known. Here, we show that a previously known secreted protein, GRA16, plays a crucial role in c-Myc upregulation. This finding will enable further dissection of the precise mechanism and role of c-Myc upregulation in Toxoplasma -infected cells.

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