The Case for Adopting the “Species Complex” Nomenclature for the Etiologic Agents of Cryptococcosis | Zendy

Kyung J. KwonChung | Zendy; John E. Bennett | Zendy; Brian L. Wickes | Zendy; Wieland Meyer | Zendy; Christina A. Cuomo | Zendy; Kurt R. Wollenburg | Zendy; Tihana Bicanic | Zendy; Elizabeth Castañeda | Zendy; Yun C. Chang | Zendy; Jianghan Chen | Zendy; Massimo Cogliati | Zendy; Françoise Dromer | Zendy; David Ellis | Zendy; Scott G. Filler | Zendy; Matthew C. Fisher | Zendy; Thomas S. Harrison | Zendy; Steven M. Holland | Zendy; Shigeru Kohno | Zendy; James W. Kronstad | Zendy; Márcia Lazéra | Zendy; Stuart M. Levitz | Zendy; Michail S. Lionakis | Zendy; Robin C. May | Zendy; Popchai Ngamskulrongroj | Zendy; Peter G. Pappas | Zendy; John R. Perfect | Zendy; Volker Rickerts | Zendy; Tania C. Sorrell | Zendy; Thomas J. Walsh | Zendy; Peter R. Williamson | Zendy; Jianping Xu | Zendy; Adrian M. Zelazny | Zendy; Arturo Casadevall | Zendy

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The Case for Adopting the “Species Complex” Nomenclature for the Etiologic Agents of Cryptococcosis

Author(s) -

Kyung J. KwonChung,

John E. Bennett,

Brian L. Wickes,

Wieland Meyer,

Christina A. Cuomo,

Kurt R. Wollenburg,

Tihana Bicanic,

Elizabeth Castañeda,

Yun C. Chang,

Jianghan Chen,

Massimo Cogliati,

Françoise Dromer,

David Ellis,

Scott G. Filler,

Matthew C. Fisher,

Thomas S. Harrison,

Steven M. Holland,

Shigeru Kohno,

James W. Kronstad,

Márcia Lazéra,

Stuart M. Levitz,

Michail S. Lionakis,

Robin C. May,

Popchai Ngamskulrongroj,

Peter G. Pappas,

John R. Perfect,

Volker Rickerts,

Tania C. Sorrell,

Thomas J. Walsh,

Peter R. Williamson,

Jianping Xu,

Adrian M. Zelazny,

Arturo Casadevall

Publication year - 2017

Publication title -

msphere

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.749

H-Index - 39

ISSN - 2379-5042

DOI - 10.1128/msphere.00357-16

Subject(s) - cryptococcus neoformans , biology , clade , cryptococcosis , cryptococcus gattii , species complex , genetic diversity , phylogenetic tree , confusion , nomenclature , population , cryptococcus , evolutionary biology , genotype , zoology , taxonomy (biology) , genetics , microbiology and biotechnology , gene , medicine , psychology , environmental health , psychoanalysis

Cryptococcosis is a potentially lethal disease of humans/animals caused by Cryptococcus neoformans and Cryptococcus gattii . Distinction between the two species is based on phenotypic and genotypic characteristics. Recently, it was proposed that C. neoformans be divided into two species and C. gattii into five species based on a phylogenetic analysis of 115 isolates. While this proposal adds to the knowledge about the genetic diversity and population structure of cryptococcosis agents, the published genotypes of 2,606 strains have already revealed more genetic diversity than is encompassed by seven species. Naming every clade as a separate species at this juncture will lead to continuing nomenclatural instability. In the absence of biological differences between clades and no consensus about how DNA sequence alone can delineate a species, we recommend using " Cryptococcus neoformans species complex" and " C. gattii species complex" as a practical intermediate step, rather than creating more species. This strategy recognizes genetic diversity without creating confusion.

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