mSphere of Influence: a Systematic Approach To Dissect Virulence Traits in Candida albicans | Zendy

J. Christian Pérez | Zendy

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mSphere of Influence: a Systematic Approach To Dissect Virulence Traits in Candida albicans

Author(s) -

J. Christian Pérez

Publication year - 2019

Publication title -

msphere

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.749

H-Index - 39

ISSN - 2379-5042

DOI - 10.1128/msphere.00258-19

Subject(s) - candida albicans , virulence , biology , microbiology and biotechnology , blueprint , genetics , computational biology , gene , mechanical engineering , engineering

J. Christian Pérez studies the interplay between Candida albicans and the mammalian host. In this mSphere of Influence article, he reflects on how "Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity" (S. M. Noble, S. French, L. A. Kohn, V. Chen, et al., Nat Genet 42:590-598, 2010, https://doi.org/10.1038/ng.605) provided tools and a blueprint for open-ended genetic screens in an organism that had been a challenge for genetic manipulation.

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