Characterization of a Type II-A CRISPR-Cas System in Streptococcus mutans | Zendy

Cas Mosterd | Zendy; Sylvain Moineau | Zendy

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Characterization of a Type II-A CRISPR-Cas System in Streptococcus mutans

Author(s) -

Cas Mosterd,

Sylvain Moineau

Publication year - 2020

Publication title -

msphere

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.749

H-Index - 39

ISSN - 2379-5042

DOI - 10.1128/msphere.00235-20

Subject(s) - crispr , streptococcus mutans , biology , genome editing , computational biology , adaptation (eye) , bacteria , microbiology and biotechnology , genetics , gene , neuroscience

CRISPR-Cas is one of the mechanisms used by bacteria to defend against viral predation. Increasing our knowledge of the biology and diversity of CRISPR-Cas systems will also improve our understanding of virus-bacterium interactions. As CRISPR-Cas systems acquiring novel immunities under laboratory conditions are rare, Streptococcus mutans strain P42S provides an alternative model to study the adaptation step, which is still the least understood step in CRISPR-Cas biology. Furthermore, the availability of a natural Cas9 protein recognizing an AT-rich PAM opens up new avenues for genome editing purposes.

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