Potential Roles of Fungal Extracellular Vesicles during Infection | Zendy

Luna S. Joffe | Zendy; Leonardo Nimrichter | Zendy; Márcio L. Rodrigues | Zendy; Maurizio Del Poeta | Zendy

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Potential Roles of Fungal Extracellular Vesicles during Infection

Author(s) -

Luna S. Joffe,

Leonardo Nimrichter,

Márcio L. Rodrigues,

Maurizio Del Poeta

Publication year - 2016

Publication title -

msphere

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.749

H-Index - 39

ISSN - 2379-5042

DOI - 10.1128/msphere.00099-16

Subject(s) - extracellular vesicles , virulence , extracellular , extracellular vesicle , biology , microbiology and biotechnology , polysaccharide , microvesicles , vesicle , rna , biochemistry , gene , microrna , membrane

Extracellular vesicles (EVs) are produced by virtually all cell types. Within the past few years, work in this field has revealed more information about fungal EVs. Fungal EVs have been shown to carry proteins, lipids, pigments, polysaccharides, and RNA; these components are known virulence factors, a fact which supports the hypothesis that fungal EVs concentrate pathogenic determinants. Additionally, recent studies have demonstrated that fungal EVs stimulate the host immune system. In this review, putative roles of fungal EVs are discussed, including their potential as vaccination tools and their possible contribution to pathogenesis in invasive fungal diseases.

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