Open AccessRegulation of the Cell Cycle by Protein Phosphatase 2A in Saccharomyces cerevisiae
Author(s) -
Yu Jiang
Publication year - 2006
Publication title -
microbiology and molecular biology reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.358
H-Index - 247
eISSN - 1098-5557
pISSN - 1092-2172
DOI - 10.1128/mmbr.00049-05
Subject(s) - protein phosphatase 2 , biology , microbiology and biotechnology , cyclin dependent kinase , polo like kinase , cytokinesis , cell cycle , mitotic exit , restriction point , cyclin dependent kinase 1 , saccharomyces cerevisiae , mitosis , cell cycle checkpoint , cell cycle protein , phosphatase , cell division , cell , genetics , yeast , phosphorylation , anaphase
SUMMARY Protein phosphatase 2A (PP2A) has long been implicated in cell cycle regulation in many different organisms. In the yeastSaccharomyces cerevisiae , PP2A controls cell cycle progression mainly through modulation of cyclin-dependent kinase (CDK) at the G2 /M transition. However, CDK does not appear to be a direct target of PP2A. PP2A affects CDK activity through its roles in checkpoint controls. Inactivation of PP2A downregulates CDK by activating the morphogenesis checkpoint and, consequently, delays mitotic entry. Defects in PP2A also compromise the spindle checkpoint and predispose the cell to an error-prone mitotic exit. In addition, PP2A is involved in controlling the G1 /S transition and cytokinesis. These findings suggest that PP2A functions in many stages of the cell cycle and its effect on cell cycle progression is pleiotropic.