N ε-Lysine Acetylation Control Conserved in All Three Life Domains

Working with microbes provides opportunities to better understand fundamental cellular processes, including some that, although discovered in eukaryotes, have their origins in Bacteria or Archaea. One such example, reversible Ne-lysine (Ne-Lys) acetylation of proteins, appears crucial for all organisms. With that universality in mind, the relative simplicity of bacteria and archaea could prove critical for advancing our understanding of how this posttranslational modification system influences cell survival.