Mutation mapping of the 2B5 ecdysone locus in Drosophila melanogaster reveals a long-distance controlling element. | Zendy

Javier Sampedro | Zendy; Joan Galcerán | Zendy; Marisol Izquierdo | Zendy

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Mutation mapping of the 2B5 ecdysone locus in Drosophila melanogaster reveals a long-distance controlling element.

Author(s) -

Javier Sampedro,

Joan Galcerán,

Marisol Izquierdo

Publication year - 1989

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.9.8.3588

Subject(s) - biology , drosophila melanogaster , genetics , locus (genetics) , ecdysone , intron , transcription (linguistics) , gene , transposable element , drosophilidae , p element , mutant , linguistics , philosophy

Mutations at the Broad-Complex, a key gene triggering metamorphosis in Drosophila melanogaster, were mapped at the DNA level. The Broad-Complex includes two mutually complementing allelic classes, br and l(1)2Bc, both of which can associate to insertions at the same intron. Alterations spreading over 50 kilobases upstream from the transcription unit also disrupt br but not l(1)2Bc function.

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