Open AccessMultiple proto-oncogene activations in avian leukosis virus-induced lymphomas: evidence for stage-specific events.
Author(s) -
Bruce E. Clurman,
William S. Hayward
Publication year - 1989
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.9.6.2657
Subject(s) - biology , oncogene , lymphoma , myb , viral oncogene , virus , cancer research , avian leukosis , locus (genetics) , phenotype , gene , oncogene proteins , virology , genetics , transcription factor , regulation of gene expression , immunology , cell cycle
We have examined avian leukosis virus-induced B-cell lymphomas for multiple, stage-specific oncogene activations. Three targets for viral integration were identified: c-myb, c-myc, and a newly identified locus termed c-bic. The c-myb and c-myc genes were associated with different lymphoma phenotypes. The c-bic locus was a target for integration in one class of lymphomas, usually in conjunction with c-myc activation. The data indicate that c-myc and c-bic may act synergistically during lymphomagenesis and that c-bic is involved in late stages of tumor progression.