Open AccessExpression of raf oncogenes activates the PEA1 transcription factor motif.
Author(s) -
Christine Wasylyk,
Bohdan Wasylyk,
Gisela Heidecker,
M Huleihel,
Ulf R. Rapp
Publication year - 1989
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.9.5.2247
Subject(s) - ap 1 transcription factor , biology , enhancer , transcription factor , phosphorylation , motif (music) , transcription (linguistics) , microbiology and biotechnology , dna binding protein , genetics , gene , linguistics , philosophy , physics , acoustics
PEA1 (AP1) motif transcription enhancer activity was stimulated by v-raf and more efficiently by activated c-raf-1 or A-raf than by their normal counterparts, in agreement with a role for PEA1 in transformation by raf. Mutations in the ATP-binding site of v-raf prevented activation, suggesting that phosphorylation is somehow required.