Expression of raf oncogenes activates the PEA1 transcription factor motif. | Zendy

Christine Wasylyk | Zendy; Bohdan Wasylyk | Zendy; Gisela Heidecker | Zendy; Mahmoud Huleihel | Zendy; Ulf R. Rapp | Zendy

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Expression of raf oncogenes activates the PEA1 transcription factor motif.

Author(s) -

Christine Wasylyk,

Bohdan Wasylyk,

Gisela Heidecker,

Mahmoud Huleihel,

Ulf R. Rapp

Publication year - 1989

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.9.5.2247

Subject(s) - ap 1 transcription factor , biology , enhancer , transcription factor , phosphorylation , motif (music) , transcription (linguistics) , microbiology and biotechnology , dna binding protein , genetics , gene , linguistics , philosophy , physics , acoustics

PEA1 (AP1) motif transcription enhancer activity was stimulated by v-raf and more efficiently by activated c-raf-1 or A-raf than by their normal counterparts, in agreement with a role for PEA1 in transformation by raf. Mutations in the ATP-binding site of v-raf prevented activation, suggesting that phosphorylation is somehow required.

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