Open AccessA moveable 5' splice site in adenine phosphoribosyltransferase genes of Drosophila species.
Author(s) -
Daniel Johnson,
Steven Henikoff
Publication year - 1989
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.9.5.2220
Subject(s) - adenine phosphoribosyltransferase , biology , gene , intron , rna splicing , splice , genetics , alternative splicing , rna , microbiology and biotechnology , messenger rna , biochemistry , enzyme , purine
In two distantly related Drosophila species, the use of alternate 5' splice sites to process an intron in pre-mRNA from homologous adenine phosphoribosyltransferase (APRT)-encoding genes led to RNAs encoding nonfunctional peptides in addition to APRT. The production of aberrantly spliced transcripts as a normal feature of gene expression supports a general model of eucaryotic gene evolution through alternative splicing and moveable splice junctions.