A moveable 5' splice site in adenine phosphoribosyltransferase genes of Drosophila species. | Zendy

Daniel H. Johnson | Zendy; Steven Henikoff | Zendy

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A moveable 5' splice site in adenine phosphoribosyltransferase genes of Drosophila species.

Author(s) -

Daniel H. Johnson,

Steven Henikoff

Publication year - 1989

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.9.5.2220

Subject(s) - adenine phosphoribosyltransferase , biology , gene , intron , rna splicing , splice , genetics , alternative splicing , rna , microbiology and biotechnology , messenger rna , biochemistry , enzyme , purine

In two distantly related Drosophila species, the use of alternate 5' splice sites to process an intron in pre-mRNA from homologous adenine phosphoribosyltransferase (APRT)-encoding genes led to RNAs encoding nonfunctional peptides in addition to APRT. The production of aberrantly spliced transcripts as a normal feature of gene expression supports a general model of eucaryotic gene evolution through alternative splicing and moveable splice junctions.

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