Open Access2,3,7,8-Tetrachlorodibenzo-p-dioxin-inducible aryl hydrocarbon receptor-mediated change in CYP1A1 chromatin structure occurs independently of transcription.
Author(s) -
Linda K. Durrin,
Jr Jp Whitlock
Publication year - 1989
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.9.12.5733
Subject(s) - chromatin , aryl hydrocarbon receptor , biology , transcription (linguistics) , tetrachlorodibenzo p dioxin , dna , transcription factor , microbiology and biotechnology , chia pet , transcription coregulator , rna , chromatin remodeling , genetics , chemistry , gene , toxicity , linguistics , philosophy , organic chemistry
2,3,7,8-Tetrachlorodibenzo-p-dioxin induces, in a receptor-dependent fashion, an increase in the accessibility of CYP1A1 chromatin to restriction endonucleases. The 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced change in chromatin structure occurs rapidly and does not require ongoing RNA or protein synthesis. The increased accessibility of chromatin DNA may facilitate its subsequent interaction with other transcription factors.