Open AccessThe FER gene is evolutionarily conserved and encodes a widely expressed member of the FPS/FES protein-tyrosine kinase family.
Author(s) -
Tony Pawson,
K Letwin,
T. Lee,
Qian-Lin Hao,
Nora Heisterkamp,
John Groffen
Publication year - 1989
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.9.12.5722
Subject(s) - biology , gene , tyrosine kinase , sh2 domain , tyrosine , conserved sequence , genetics , gene family , receptor tyrosine kinase , peptide sequence , microbiology and biotechnology , kinase , signal transduction , gene expression , biochemistry
We have recently isolated human and rat cDNAs (designated FER and flk, respectively) which encode nonreceptor protein-tyrosine kinases which are very similar to one another and related in sequence and domain structure to the c-fps/fes gene product. We show that FER and flk are human and rat counterparts of an evolutionarily conserved gene, hereafter termed FER regardless of species. The human and rat FER genes encode a widely expressed 94-kilodalton protein-tyrosine kinase which is antigenically related to the fps/fes protein-tyrosine kinase. The structural and antigenic similarities between the FER and fps/fes proteins suggest that they are members of a new family of nonreceptor protein-tyrosine kinases.