The Saccharomyces cerevisiae SPT13/GAL11 gene has both positive and negative regulatory roles in transcription. | Zendy

Jan S. Fassler | Zendy; Fred Winston | Zendy

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The Saccharomyces cerevisiae SPT13/GAL11 gene has both positive and negative regulatory roles in transcription.

Author(s) -

Jan S. Fassler,

Fred Winston

Publication year - 1989

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.9.12.5602

Subject(s) - biology , gene , genetics , transcription (linguistics) , saccharomyces cerevisiae , mutant , regulator gene , gene expression , pair rule gene , transcription factor , regulation of gene expression , philosophy , linguistics

To understand the function of SPT13, a gene encoding a trans-acting factor involved in regulation of Ty-mediated gene expression, we have cloned and sequenced the gene. Our analysis revealed that SPT13 is the same gene as GAL11, a gene in which mutations cause reduced expression of some GAL4-regulated genes. Further analysis of spt13/gal11 mutants suggested that the SPT13 gene also affects transcription of genes involved in mating-type specialization. We show here that SPT13 has both positive and negative regulatory roles in transcription.

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