Expression of the yes proto-oncogene in cerebellar Purkinje cells. | Zendy

Marius Sudol | Zendy; C. Frank Kuo | Zendy; Lucy Shigemitsu | Zendy; Arturo Álvarez-Buylla | Zendy

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Expression of the yes proto-oncogene in cerebellar Purkinje cells.

Author(s) -

Marius Sudol,

C. Frank Kuo,

Lucy Shigemitsu,

Arturo Álvarez-Buylla

Publication year - 1989

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.9.10.4545

Subject(s) - biology , cerebellum , in situ hybridization , purkinje cell , mutant , microbiology and biotechnology , oncogene , gene , staining , gene expression , messenger rna , gene product , neuroscience , genetics , cell cycle

To identify the kinds of cells in the brain that express the yes proto-oncogene, we examined chicken brains by using immunofluorescent staining and in situ hybridization. Both approaches showed that the highest level of the yes gene product was in cerebellar Purkinje cells. In addition, we analyzed Purkinje cell degeneration (pcd) mutant mice. The level of yes mRNA in cerebella of pcd mutants was four times lower than that found in cerebella of normal littermates. Our studies point to Purkinje cells as an attractive model for functional studies of the yes protein.

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