Open AccessPerturbation of chromatin architecture on ecdysterone induction of Drosophila melanogaster small heat shock protein genes.
Author(s) -
Susan E. Kelly,
Iain L. Cartwright
Publication year - 1989
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.9.1.332
Subject(s) - biology , drosophila melanogaster , ecdysterone , chromatin , gene , genetics , hypersensitive site , transcription (linguistics) , drosophilidae , heat shock protein , microbiology and biotechnology , heat shock factor , gene expression , hsp70 , promoter , biochemistry , linguistics , philosophy , hormone
Alterations in the pattern of DNase I hypersensitivity were observed on ecdysterone-stimulated transcription of Drosophila melanogaster small heat shock protein genes. Perturbations were induced near hsp27 and hsp22, coupled with an extensive domain of chromatin unfolding in the intergenic region between hsp23 and the developmentally regulated gene 1. These regions represent candidates for ecdysterone regulatory interactions.