Differential expression of a tropomyosin isoform in low- and high-metastatic Lewis lung carcinoma cells. | Zendy

Keizo Takenaga | Zendy; Yohko Nakamura | Zendy; S Sakiyama | Zendy

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Differential expression of a tropomyosin isoform in low- and high-metastatic Lewis lung carcinoma cells.

Author(s) -

Keizo Takenaga,

Yohko Nakamura,

S Sakiyama

Publication year - 1988

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.8.9.3934

Subject(s) - lewis lung carcinoma , biology , gene isoform , tropomyosin , metastatic carcinoma , cancer research , phenotype , incubation , microbiology and biotechnology , carcinoma , lung cancer , metastasis , medicine , biochemistry , cancer , gene , actin , genetics

Two-dimensional electrophoretograms of newly synthesized polypeptides from low-metastatic (P29) and high-metastatic (D6) Lewis lung carcinoma cells were compared. The results showed that the synthesis of tropomyosin 2 (TM2) was significantly less in D6 cells than in P29 cells. Furthermore, suppression of TM2 synthesis was induced in P29 cells during incubation in medium containing dimethyl sulfoxide or butyric acid, which induced the metastatic phenotype of P29 cells. These results suggest that the suppression of TM2 synthesis is linked to the metastatic potential of Lewis lung carcinoma cells.

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