Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6. | Zendy

T Satoh | Zendy; S Nakamura | Zendy; Tetsuya Taga | Zendy; Tadashi Matsuda | Zendy; T Hirano | Zendy; T Kishimoto | Zendy; Y Kaziro | Zendy

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Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6.

Author(s) -

T Satoh,

S Nakamura,

Tetsuya Taga,

Tadashi Matsuda,

T Hirano,

T Kishimoto,

Y Kaziro

Publication year - 1988

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.8.8.3546

Subject(s) - biology , neurite , lymphokine , microbiology and biotechnology , cell culture , cellular differentiation , immunology , immune system , in vitro , gene , biochemistry , genetics

B-cell stimulatory factor 2 (BSF-2) is a lymphokine which induces the final maturation of B cells. BSF-2 acts on a variety of cells other than B cells, and moreover, expression of BSF-2 mRNA is detected in interleukin-1 beta-stimulated glioblastoma and astrocytoma cell lines. Here, we studied the function of BSF-2 on pheochromocytoma PC12 cells, a model system for induction of neuronal differentiation. PC12 cells possess specific receptors for BSF-2. The BSF-2-stimulated PC12 cells expressed the c-fos proto-oncogene transiently, and they began to change morphologically to neurite-extending cells after several days. The number of voltage-dependent Na+ channels was also increased.

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