Open AccessAbsence of missense mutations in activated c-myc genes in avian leukosis virus-induced B-cell lymphomas.
Author(s) -
Mounou Hahn,
William S. Hayward
Publication year - 1988
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.8.6.2659
Subject(s) - biology , gene , missense mutation , avian leukosis , virus , mutation , oncogene , genetics , gene product , virology , microbiology and biotechnology , gene expression , cell cycle
We have determined the nucleotide sequences of two independent DNA clones which contained the activated c-myc genes from avian leukosis virus-induced B-cell lymphomas. Neither of these c-myc genes contained missense mutations. This strongly supports the notion that the c-myc proto-oncogene in avian leukosis virus-induced B-cell lymphomas can be oncogenically activated by altered expression of the gene without a change in the primary structure of the gene product.