Absence of missense mutations in activated c-myc genes in avian leukosis virus-induced B-cell lymphomas. | Zendy

Mounou Hahn | Zendy; W S Hayward | Zendy

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Absence of missense mutations in activated c-myc genes in avian leukosis virus-induced B-cell lymphomas.

Author(s) -

Mounou Hahn,

W S Hayward

Publication year - 1988

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.8.6.2659

Subject(s) - biology , gene , missense mutation , avian leukosis , virus , mutation , oncogene , genetics , gene product , virology , microbiology and biotechnology , gene expression , cell cycle

We have determined the nucleotide sequences of two independent DNA clones which contained the activated c-myc genes from avian leukosis virus-induced B-cell lymphomas. Neither of these c-myc genes contained missense mutations. This strongly supports the notion that the c-myc proto-oncogene in avian leukosis virus-induced B-cell lymphomas can be oncogenically activated by altered expression of the gene without a change in the primary structure of the gene product.

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