Open AccessDecreased expression of the stress protein HSP70 is an early event in murine erythroleukemic cell differentiation.
Author(s) -
J O Hensold,
D E Housman
Publication year - 1988
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.8.5.2219
Subject(s) - biology , inducer , cellular differentiation , hsp70 , microbiology and biotechnology , gene expression , cell , gene , genetics , heat shock protein
Two-dimensional protein gels were used to systematically assess changes in gene expression in Friend erythroleukemia cells after exposure to inducers of differentiation. A rapid decrease in expression of the stress protein HSP70 was observed after exposure to inducers. The kinetics of this change suggest that it may be related to the cellular events that regulate the onset of differentiation.