Regulation of c-myb expression in human neuroblastoma cells during retinoic acid-induced differentiation. | Zendy

Carol J. Thiele | Zendy; P S Cohen | Zendy; Mark A. Israel | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Regulation of c-myb expression in human neuroblastoma cells during retinoic acid-induced differentiation.

Author(s) -

Carol J. Thiele,

P S Cohen,

Mark A. Israel

Publication year - 1988

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.8.4.1677

Subject(s) - biology , retinoic acid , myb , neuroblastoma , haematopoiesis , transcription factor , retinoic acid inducible orphan g protein coupled receptor , cellular differentiation , microbiology and biotechnology , oncogene , cell culture , cancer research , retinoic acid receptor , cell , stem cell , gene , cell cycle , biochemistry , genetics

We detected expression of the c-myb proto-oncogene, which was initially thought to be expressed in a tissue-specific manner in cells of hematopoietic lineage, in human tissues of neuronal origin. Since the level of c-myb expression declined during fetal development, we studied the regulation of its expression in human neuroblastoma cell lines induced to differentiate by retinoic acid. The expression of c-myb declined during the maturation of neuroblastoma cells, and this change was mediated by a decrease in c-myb transcription.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research