Open AccessRegulation of c-myb expression in human neuroblastoma cells during retinoic acid-induced differentiation.
Author(s) -
Carol J. Thiele,
Pamela S. Cohen,
Mark A. Israel
Publication year - 1988
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.8.4.1677
Subject(s) - biology , retinoic acid , myb , neuroblastoma , haematopoiesis , transcription factor , retinoic acid inducible orphan g protein coupled receptor , cellular differentiation , microbiology and biotechnology , oncogene , cell culture , cancer research , retinoic acid receptor , cell , stem cell , gene , cell cycle , biochemistry , genetics
We detected expression of the c-myb proto-oncogene, which was initially thought to be expressed in a tissue-specific manner in cells of hematopoietic lineage, in human tissues of neuronal origin. Since the level of c-myb expression declined during fetal development, we studied the regulation of its expression in human neuroblastoma cell lines induced to differentiate by retinoic acid. The expression of c-myb declined during the maturation of neuroblastoma cells, and this change was mediated by a decrease in c-myb transcription.