The testis-specific phosphoglycerate kinase gene pgk-2 is a recruited retroposon. | Zendy

Poppo H. Boer | Zendy; Chaker N. Adra | Zendy; YunFai Chris Lau | Zendy; Michael W. McBurney | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The testis-specific phosphoglycerate kinase gene pgk-2 is a recruited retroposon.

Author(s) -

Poppo H. Boer,

Chaker N. Adra,

YunFai Chris Lau,

Michael W. McBurney

Publication year - 1987

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.7.9.3107

Subject(s) - phosphoglycerate kinase , biology , retroposon , gene , gene duplication , intron , genetics , nucleic acid sequence , microbiology and biotechnology , genome , transposable element

In both humans and mice, two genes encode phosphoglycerate kinase, a key enzyme in the glycolytic pathway. The pgk-1 gene is expressed in all somatic cells, is located on the X chromosome, and contains 10 introns. The pgk-2 gene is expressed only in sperm cells, is located on an autosome, and has no introns. The nucleotide sequence of the pgk-2 gene suggests that it arose from pgk-1 more than 100 million years ago by RNA-mediated gene duplication. The pgk-2 gene may, then, be a transcribed retroposon. Thus, gene duplication by retroposition may have been used as a mechanism for evolutionary diversification.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research