Open AccessFunctional simian virus 40 T antigen is expressed in hybrid cells having finite proliferative potential.
Author(s) -
Olivia M. PereiraSmith,
James R. Smith
Publication year - 1987
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.7.4.1541
Subject(s) - biology , simian , virus , virology , cell division , microbiology and biotechnology , antigen , cell culture , cell , genetics
Simian virus 40-transformed human cells fused with other independently derived simian virus 40-transformed cells and tumor-derived cells containing activated H-ras and N-ras oncogenes yielded hybrids capable of indefinite division. Fusions with various other immortal cells yielded hybrids that had limited division potential. T antigen expressed in limited-division hybrids was functional for the induction of cellular DNA synthesis.