Functional simian virus 40 T antigen is expressed in hybrid cells having finite proliferative potential. | Zendy

Olivia M. PereiraSmith | Zendy; James R. Smith | Zendy

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Functional simian virus 40 T antigen is expressed in hybrid cells having finite proliferative potential.

Author(s) -

Olivia M. PereiraSmith,

James R. Smith

Publication year - 1987

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.7.4.1541

Subject(s) - biology , simian , virus , virology , cell division , microbiology and biotechnology , antigen , cell culture , cell , genetics

Simian virus 40-transformed human cells fused with other independently derived simian virus 40-transformed cells and tumor-derived cells containing activated H-ras and N-ras oncogenes yielded hybrids capable of indefinite division. Fusions with various other immortal cells yielded hybrids that had limited division potential. T antigen expressed in limited-division hybrids was functional for the induction of cellular DNA synthesis.

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