Open AccessDetection of c-rel-related transcripts in mouse hematopoietic tissues, fractionated lymphocyte populations, and cell lines.
Author(s) -
Elise Brownell,
Bonnie J. Mathieson,
Howard A. Young,
J Keller,
James N. Ihle,
Nancy R. Rice
Publication year - 1987
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.7.3.1304
Subject(s) - biology , retrovirus , haematopoiesis , reticuloendotheliosis virus , microbiology and biotechnology , murine leukemia virus , myb , gene , lymphocyte , cell culture , virology , gene expression , genetics , stem cell
A portion of the human cellular homolog of v-rel, the transforming gene of the leukemogenic retrovirus reticuloendotheliosis virus, strain T, was used to survey RNAs from several mouse tissues, selected lymphocyte populations, and hematopoietic cell lines for c-rel expression. Relatively high levels of a high-molecular-weight transcript were observed in peripheral B and T cells, whereas lower levels were detectable in functionally immature thymocytes. These results suggested that, unlike c-myb and c-ets, the c-rel proto-oncogene plays a role in later stages of lymphocyte differentiation.