rasH mutants deficient in GTP binding. | Zendy

Channing J. Der | Zendy; BinTao Pan | Zendy; Geoffrey M. Cooper | Zendy

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rasH mutants deficient in GTP binding.

Author(s) -

Channing J. Der,

BinTao Pan,

Geoffrey M. Cooper

Publication year - 1986

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.6.9.3291

Subject(s) - gtp' , biology , mutant , gtp binding protein regulators , biochemistry , binding site , plasma protein binding , g protein , dna binding protein , microbiology and biotechnology , receptor , enzyme , gene , transcription factor

Single amino acid substitutions were introduced into a region of the rasH protein (residues 116, 117, and 119) homologous to a variety of diverse GTP-binding proteins. Each of the mutant p21 proteins displayed a significant reduction (10- to 5,000-fold) in GTP binding affinity. Activated rasH proteins deficient in GTP binding were unaltered in their ability to morphologically transform NIH 3T3 cells.

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