Point mutation associated with hereditary persistence of fetal hemoglobin decreases RNA polymerase III transcription upstream of the affected gamma-globin gene. | Zendy

David P. Carlson | Zendy; Jeffrey Ross | Zendy

Open Access

Point mutation associated with hereditary persistence of fetal hemoglobin decreases RNA polymerase III transcription upstream of the affected gamma-globin gene.

Author(s) -

David P. Carlson,

Jeffrey Ross

Publication year - 1986

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.6.9.3278

Subject(s) - biology , rna polymerase ii , transcription (linguistics) , microbiology and biotechnology , point mutation , polymerase , rna polymerase iii , fetal hemoglobin , gene , general transcription factor , transcription factor ii d , globin , rna polymerase , genetics , rna , promoter , gene expression , fetus , mutation , pregnancy , linguistics , philosophy

A base substitution in the 5'-flanking region of a human fetal globin gene is associated with abnormal fetal hemoglobin production. It also reduces by 5- to 10-fold in vitro transcription of the gene by RNA polymerase III. We discuss potential links between polymerase III transcription and abnormal hemoglobin production.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research