Anemia induces accumulation of erythropoietin mRNA in the kidney and liver. | Zendy

Maurice C. Bondurant | Zendy; Mark J. Koury | Zendy

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Anemia induces accumulation of erythropoietin mRNA in the kidney and liver.

Author(s) -

Maurice C. Bondurant,

Mark J. Koury

Publication year - 1986

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.6.7.2731

Subject(s) - erythropoietin , biology , messenger rna , socs2 , kidney , hemoglobin , microbiology and biotechnology , endocrinology , gene , biochemistry , suppressor

Regulation of the production of erythropoietin occurs in the kidney and liver largely through control of accumulation of erythropoietin mRNA. Erythropoietin mRNA was first detected in kidneys at 1.5 h postanemia and reached a plateau value at least 200-fold above the control value by 4 to 8 h. A 20-base sequence immediately upstream from the reported erythropoietin mRNA initiation site is complementary to a hypervariable sequence in 18S rRNA.

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