Open AccessAbelson virus abrogation of interleukin-3 dependence in a lymphoid cell line.
Author(s) -
Bernard Mathey-Prévôt,
Gary J. Nabel,
Ronald Palacios,
David Baltimore
Publication year - 1986
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.6.11.4133
Subject(s) - biology , lymphokine , tyrosine kinase , kinase , virology , microbiology and biotechnology , cancer research , immunology , signal transduction , immune system
Among several tyrosine-protein kinases, only v-abl could abrogate interleukin 3 dependence of a lymphoblastoid cell line; v-src and v-fps proteins gave partial or no interleukin 3 independence, respectively. Lymphokine independence was achieved via a nonautocrine mechanism. Direct involvement of c-myc in this process was not evident.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom