Open AccessInterferon-induced human protein with homology to protein Mx of influenza virus-resistant mice.
Author(s) -
Peter Staeheli,
Otto Haller
Publication year - 1985
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.5.8.2150
Subject(s) - biology , polyclonal antibodies , virology , microbiology and biotechnology , interferon , virus , monoclonal antibody , retinoblastoma like protein 1 , protein a/g , cytoplasm , antibody , interferon gamma , homology (biology) , alpha interferon , gene , fusion protein , cytokine , immunology , recombinant dna , genetics
Polyclonal and monoclonal antibodies with specificity for protein Mx (a karyophilic 75,000-dalton protein induced by interferon [IFN] in mouse cells carrying the influenza virus resistance allele Mx+) detected an IFN-induced 80,000-dalton protein in peripheral blood lymphocytes and in fibroblasts of healthy human donors. The human protein, like protein Mx, was induced by IFN-alpha but not by IFN-gamma. Unlike the mouse protein, it was predominantly localized in the cell cytoplasm.
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