Recombination hot spot in the human beta-globin gene cluster: meiotic recombination of human DNA fragments in Saccharomyces cerevisiae. | Zendy

Douglas A. Treco | Zendy; B Thomas | Zendy; Norman Arnheim | Zendy

Open Access

Recombination hot spot in the human beta-globin gene cluster: meiotic recombination of human DNA fragments in Saccharomyces cerevisiae.

Author(s) -

Douglas A. Treco,

B Thomas,

Norman Arnheim

Publication year - 1985

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.5.8.2029

Subject(s) - biology , flp frt recombination , genetic recombination , saccharomyces cerevisiae , recombination , non allelic homologous recombination , genetics , homologous recombination , meiosis , gene conversion , dna , locus (genetics) , microbiology and biotechnology , gene

We describe a novel system for the analysis of sequence-specific meiotic recombination in Saccharomyces cerevisiae. A comparison of three adjacent restriction fragments from the human beta-globin locus revealed that one of them, previously hypothesized to contain a relative hot spot for genetic recombination, engages in reciprocal exchange during yeast meiosis significantly more frequently than either of the other two fragments. Removal of the longest of four potential Z-DNA-forming regions from this fragment does not affect the high frequency of genetic recombination.

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