Human c-fms proto-oncogene: comparative analysis with an abnormal allele. | Zendy

J S Verbeek | Zendy; A.J.M. Roebroek | Zendy; A M van den Ouweland | Zendy; Henri P.J. Bloemers | Zendy; W J Van de Ven | Zendy

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Human c-fms proto-oncogene: comparative analysis with an abnormal allele.

Author(s) -

J S Verbeek,

A.J.M. Roebroek,

A M van den Ouweland,

Henri P.J. Bloemers,

W J Van de Ven

Publication year - 1985

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.5.2.422

Subject(s) - biology , allele , locus (genetics) , genetics , exon , dna , homologous chromosome , human genetics , oncogene , base pair , microbiology and biotechnology , gene , cell cycle

The organization of the human c-fms proto-oncogene has been determined and compared with an abnormal allele. The human v-fms homologous genetic sequences are dispersed discontinuously and colinearly with the viral oncogene over a DNA region of ca. 32 kilobase pairs. The abnormal c-fms locus contains a small deletion in its 3' portion. DNA sequencing analysis indicated that it was 426 base pairs in size and located in close proximity to a putative c-fms exon.

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